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Nonetheless, in a small crossover study of 26 human diabetic patients, 4 weeks of ebselen treatment did not alter plasma levels of oxidative stress markers, such as GSH/GSSG, isoprostanes, and nitrotyrosine, compared to placebo treatment [82]

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Preserved incretin activity of glucagon-like peptide 1 (GLP-1) [7-36 amide] but not of synthetic gastric inhibitory polypeptide (GIP) in patients with type 2-diabetes mellitus