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10.1038/s41593-022-01221-3 91 SanaeifarF.PourranjbarS.PourranjbarM.RamezaniS.MehrS

Nature cancer

Given that melatonin is a small amphiphilic molecule (61), its intracellular actions do not necessarily require engagement of surface receptors

In HT-22 (mouse hippocampal neurons cells) cells, Fer-1 notably decreases both cytoplasmic and lipid ROS levels, counteracts glutamate-induced suppression of GSH and GPX activity and protects against oxidative toxicity

Despite these promising developments, translating microglial modulation into effective clinical therapies presents formidable challenges

M., Gao, X., Dai, Z., & Locasale, J