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Infection and Immunometabolism in the Central Nervous System: A Possible Mechanistic Link between Metabolic Imbalance and Dementia

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In the Krebs cycle, NAD+ functions as a coenzyme for the rate-limiting enzymes alpha ketoglutarate dehydrogenase, isocitrate dehydrogenase, and malate dehydrogenase

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It's a chemical reaction that depends on a lot of variables, well beyond any modeling you can do with an on-line calculator

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