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However, a retrospective cohort study of electronic health records involving 240,618 patients with overweight or obesity prescribed semaglutide or non-GLP-1 receptor agonist antiobesity medications, and 1,589,855 patients with type 2 diabetes prescribed semaglutide or other hypoglycaemic agents, found a lower risk of suicidal ideation in patients prescribed semaglutide regardless of prior psychiatric history
Several GLP-1 RAs have additional FDA approval for: Heart protection : Dulaglutide [archived link], liraglutide [archived link], and semaglutide [archived link] have been proven to prevent strokes and heart attacks in people with risk factors, such as diabetes or obesity
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Additionally, the bidirectional relation between neuroinflammation and neuronal injury requires further investigation