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It is obtained from the diet, while in vivo, it is primarily synthesized by the kidneys, pancreas, and liver

The associations of TMAO with inflammation, endothelial dysfunction, type 2 diabetes, central adiposity, hypertension, and cancer [37,38,39] have led to a growing interest in this metabolite

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G6PD deficiency reduces the amount of NADPH, which is required for the formation of nitric oxide (NO) [10, 11]

Microdosing advocates claim it can help with weight loss by reducing cravings, better metabolic health, reduce inflammation, enhance mood and cognitive function, and even potentially improve longevity, all while coming with fewer side effects and being more affordable than larger doses