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Many factors, such as age, menopausal status, hormonal therapy, lactation, family history, and high-penetrance germline mutations (e.g., BRCA1/2), all shape individual risk 10

Mol Cell 73:354-363e353 Tang D, Chen X, Kang R, Kroemer G (2021) Ferroptosis: molecular mechanisms and health implications

Nevertheless, these evaluations often depend on short-term trial results projected across lifetime horizons, so injecting uncertainty over long-term efficacy and safety

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It is the major component of Lewy bodies in both sporadic and inherited forms of Parkinsons disease and in Lewy body dementia

The trial included a 24-week extension period at doses of 9 or 12 mg for about 500 adults with a BMI of 35 or greater, which is classified as severe obesity