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74,75 Moreover, previous studies have confirmed that GLP-1 upregulates SIRT1 expression in adipose tissue and ameliorates IR in PCOS mice

Nausea The most commonly reported side effect

This mechanism helps reduce food intake naturally and effectively

Regarding CV safety, large observational studies in COPD find no increased MI risk with short-acting inhaled -agonists (SABA), whereas new initiation of long-acting -agonists (LABA) has been linked to a ~ 1.5-fold increase in severe cardiovascular events within 30 days [99, 100]

While generally mild and self-limiting, persistent diarrhea warrants medical attention to prevent dehydration and assess for other potential causes

It's also wise to avoid high-fat, greasy, or very sweet foods, as they can be harder to digest and may worsen symptoms