For most patients, these early effects come and go and improve as the body adapts especially when treatment starts at a low dose and increases gradually
doi: 10.5507/bp.2016.044 113 PanH.YangS.KulyarM
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Not everyone, however, has a great response to GLP-1 drugs and they can cause unpleasant side effects, like nausea, constipation and diarrhoea
These represent a newer and more controversial delivery method
4a,b) support a mechanism in which mitochondrial complex I inhibition promotes antioxidant gene expression and NADPH production, leading to TXNIP suppression and subsequent GLUT1 upregulation