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Carotenoids undergo oxidative cleavage by the enzyme carotenoid dioxygenase, producing vitamin A and other smaller metabolites that play essential roles in vision, growth, and immune function [32]

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Materials and methods All animal experiments were approved by the Animal Care and Use Committee of Wenzhou Medical University and Ethics Committees of Wenzhou Medical University

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GHK binds copper because of a specific combination of functional groups that together form a high-affinity copper-coordination site: the N-terminal amine donates one nitrogen ligand, the histidine imidazole donates a second nitrogen ligand, and the deprotonated amide nitrogen of the Gly-His peptide bond donates a third nitrogen ligand