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We merged genes from the three databases to create a gene set for each pathway (Additional file 1: Tables S2S4), resulting in 5325, 2557, and 3435 genes for Most Studied Pathways, Gene-Associated Pathways, and Popular Pathways, respectively

In animal and cellular models, metformin reduces cardiomyocyte hypertrophy and lactate dehydrogenase release by downregulating HIF-1 and PPAR-, implicating the HIF-1/PPAR- axis in limiting pathological growth (Liu et al., 2022)

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Current status and future prospects of protein vaccine candidates against Schistosoma mansoni infection

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