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Current PCOS guidance recommends effective contraception with GLP-1 receptor agonists because pregnancy safety data are lacking

Humans express three genes in the LPIN family, LPIN1, LPIN2, and LPIN3

Hepatology 21 , 570583 (1995)

Pregnancy and breastfeeding: GLP-1 receptor agonists are not recommended during pregnancy or breastfeeding

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Some estrogen is necessary and beneficial for bone health, brain function, and cardiovascular protection