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Several previous studies have concluded that aberrant, non-native disulfide bonds involving Cys-6 and Cys-111 result in inclusion formation and disulfide reduction (Deng et al., 2006

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Mitochondrial Dysfunction and Oxidative Stress Hepatic mitochondrial dysfunction has a critical role in the development of MASLD by increasing oxidative stress, contributing to inflammation and impaired hepatic insulin resistance (4)

: "Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway." in: Cardiovascular diabetology , Vol