The lactulose:mannitol permeability ratio is increased in patients ingesting nonsteroidal anti-inflammatory drugs (NSAIDs), alcohol and some chemotherapeutic compounds [2]
Additionally, high doses of folic acid (exceeding 0.1 mg per day) may result in hematologic remission in patients with vitamin B12 deficiency
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You should not take Imigran if you: Are allergic to sumatriptan Have heart disease such as angina or a history of heart attack Have circulation problems in your legs (peripheral vascular disease) Have had a stroke or transient ischaemic attack (TIA) Have uncontrolled high blood pressure Have severe liver disease Are taking medicines containing ergotamine or similar medicines such as methysergide Are taking other triptans (5-HT1 receptor agonists) Are taking MAOIs or have taken them in the last 2 weeks If you are pregnant, speak to a healthcare professional before using Imigran
Nevertheless, supplementation should ideally be guided by clinical assessment and, where appropriate, blood testing to confirm deficiency before commencing long-term high-dose therapy
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