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doi: 10.1016/j.nut.2022.111742 111 ChenBShiYZhangKChangYFuPLiuPet al

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IGF-I/IGF-IR signaling in osteoclasts Studies of global IGF-I KO mice showed fewer (76% of WT control) and smaller osteoclasts with fewer nuclei in the bone (65), indicating impaired osteoclastogenesis and bone resorption (Figure 2)

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