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The gut microbiota plays a pivotal role, producing metabolites and neurotransmitters that influence brain function via the vagus nerve and enteric nervous system, while the hypothalamicpituitaryadrenal (HPA) axis modulates stress responses, impacting both gut and brain functions (Yang et al., 2018

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GLS overexpression has been observed in different tumor cells, and these enzymes are found to function in the metabolic reprogramming of glutamine addiction in cancer 198

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In conditions such as Crohn's, celiac disease, or pernicious anemia, the gut cannot absorb B12 from food well