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Nitric oxide induces apoptosis via triggering mitochondrial permeability transition

These include certain antipsychotics (olanzapine, clozapine), mood stabilizers (valproate, lithium), antidepressants (mirtazapine, paroxetine), corticosteroids, and some diabetes medications like insulin or sulfonylureas

Some also argued that clinicians and pharmacists should be able to weigh uncertainty for an individual patient when conventional options are inadequate

Ozempic is covered under every provincial drug plan for Type 2 diabetes, but requires Special Authority and clinical criteria (typically HbA1c above target despite metformin, with prior therapy failure documented)

On the genetic side, research by Heun and Maier (1993) showed that BP-II may be genetically different from BP-I and unipolar depression

Clin Endocrinol (Oxf) (2004) 61:40513