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The World Health Organisation's 2026 global guidelines on GLP-1 therapies for obesity explicitly recommend combining medication with intensive behavioural interventions, including structured goal-setting for diet and physical activity

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SH-SY5Y cells were seeded in 96-well plates at a density of ~ 5000/ per well, and they were exposed to various concentrations (10, 25, 50, 100, and 200 g/mL) of DNZ-NLPs for 24 h

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Data distribution for in vivo pharmacology studies was assumed to be normal, but this was not formally tested

red-flag features such as suspected scarring alopecia or rapidly progressive loss warrant prompt dermatology referral