Therefore, this review highlights that rather than potential concerns [1], these factors serve as a strong beneficial impetus for stable gastric pentadecapeptide BPC 157 therapy [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40]
[Ref] Gastrointestinal Very common (10% or more): Diarrhea (57.9%), abdominal pain (43.9%), nausea (29.8%), flatulence (25.3%), constipation (18.8%), abdominal pain upper (10.5%), abdominal discomfort, loose stools Common (1% to 10%): Fat malabsorption, vomiting, dyspepsia, steatorrhea, discoloration of feces, tenesmus, abdominal distension Uncommon (0.1% to 1%): GI bleeding, hemorrhoids, appendicitis, gastric/peptic ulcer Frequency not reported : Pancreatitis, vomiting, abnormal stools, severe epigastric pain, abdominal tenderness and guarding Postmarketing reports : Intestinal obstruction [Ref] Cardiovascular Very common (10% or more): Bradycardia (25%), hypertension (12.6%), conduction abnormalities (10%) Common (1% to 10%): Arrhythmias, flushing Uncommon (0.1% to 1%): Chest pain, shortness of breath, thrombophlebitis, ischemia, congestive heart failure, palpitations, orthostatic blood pressure decrease, tachycardia [Ref] Hepatic Very common (10% or more): Gallstones (27%), sludge without stones (24%), cholelithiasis (38.2%), biliary duct dilatation (12%) Common (1% to 10%): Transaminase increased Uncommon (0.1% to 1%): Hepatitis, jaundice, increase in liver enzymes, gallbladder polyp Rare (less than 0.1%): Acute pancreatitis Frequency not reported : Acute cholecystitis, ascending cholangitis, biliary obstruction, cholestatic hepatitis, pancreatitis [Ref] Nervous system Very common (10% or more): Headache (30%), dizziness (20%) Uncommon (0.1% to 1%): Syncope, tremor, seizure, vertigo, Bell's palsy, pituitary apoplexy, amnesia, neuritis [Ref] Metabolic Very common (10% or more): Hyperglycemia (16%) Common (1% to 10%): Hypoglycemia, edema, anorexia Uncommon (0.1% to 1%): Weight loss, dehydration Frequency not reported : Depressed vitamin B12 levels, abnormal Schilling's test [Ref] Hematologic Very common (10% or more): Anemia (15.3%) Uncommon (0.1% to 1%): Iron deficiency Postmarketing reports : Thrombocytopenia [Ref] Endocrine Very common (10% or more): Biochemical hypothyroidism (12%) Common (1% to 10%): Goiter, thyroid dysfunction (e.g
It can be associated with other symptoms such as a metallic taste, loss of taste, dry mouth, and increased thirst
Such statements assume that all pastures are severely overgrazed with so much bare soil in between plants, and grasses so poorly anchored in the soil that theyre easily pulled up by grazing herbivores, that its not even funny
No Reported Event Equals Safe Very small studies may be incapable of identifying uncommon, delayed or population-specific risks
Molecular Genetics and Metabolism 98 (12): 173180
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