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Why The Results Differ From Previous Clinical Trials Earlier randomized trials including the STEP 1 extension for semaglutide and the SURMOUNT-4 trial for tirzepatide found that patients who stopped these medications regained a significant portion of their lost weight within a year
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Int J Obes (Lond) 36:843854
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Multiple randomized controlled trials demonstrate that GLP-1 receptor agonists produce 15-22% average body weight loss over 68 weeks, with cardiovascular benefits including reduced blood pressure and improved metabolic markers
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