The RRP consists of a small fraction of total vesicles that are physically docked at the active zone, molecularly primed by active zone proteins (such as RIM and Munc13) into a SNARE-assembled, fusion-competent state (Kaeser and Regehr, 2017)
Others add less water for "stronger" doses, making precise measurement more difficult
doi: 10.2147/JIR.S353467 304 ZhangT.TsutsukiH.IslamW.OnoK.TakedaK.AkaikeT.et al
However, during oxidative stress, large or excessive amounts of these ROS can be produced and may be dangerous and harmful to the body
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