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Much of the clinical rationale rests on shorter-term pharmacology, mechanism-based reasoning, and accumulated compounding-pharmacy clinical experience rather than gold-standard RCT data

While the intravenous (IV) route has historically been the most widely used, the subcutaneous (SC) route is now accepted and presented as safe and effective, whether in the context of chronic disease or in palliative care

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Findings suggest that it may initiate signaling cascades involving PI3K and AMPK, pathways associated with nutrient regulation and energy use

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