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Tissue repair mechanisms rely heavily on growth hormone signaling

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doi: 10.1007/s12020-014-0361-4 13 ChengLHuYLiYYCaoXBaiNLuTTet al

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It is investigational and is being studied in Eli Lilly's Phase 3 TRIUMPH (obesity-focused) and TRANSCEND-T2D (type 2 diabetes) programs

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It contributes to blood glucose control by stimulating glucose-dependent insulin secretion, inhibiting glucagon release, delaying gastric emptying, and reducing appetite

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Efficacy and safety of oral Orforglipron in patients with type 2 diabetes: a multicentre, randomised, dose-response, phase 2 study

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Two of the five trials found evidence of active improvement better sperm shape and increased testosterone particularly in men whose low testosterone is caused by obesity

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