A pesar de ello, su uso no se recomienda en pacientes con neoplasia endocrina mltiple (MEN-2), antecedentes de cncer medular de tiroides, enfermedad heptica, embarazadas y lactantes, y se debe usar con precaucin en pacientes con antecedentes de colelitiasis, pancreatitis o enfermedad inflamatoria intestinal (10)
3.3.2 Regulation of hepatic lipid metabolism Triple receptor agonists exhibit promising synergistic effects on hepatic lipid metabolism, a central pathological feature in MASLD
These reductions appear to result from weight loss, improved insulin sensitivity, and potentially increased sodium excretion
Most clinicians start with a detailed medication and health review, then order targeted tests to set a baseline and catch contraindications
Food and Drug Administration Wegovy (semaglutide) prescribing information Official dosing, administration, and safety labeling Medication Manufacturer Instructions Novo Nordisk Wegovy Injection Instructions Official injection technique and pen usage Eli Lilly and Company Mounjaro (tirzepatide) Instructions for Use Proper administration and dosing schedule Evidence-Based Research New England Journal of Medicine Once-Weekly Semaglutide in Adults with Overweight or Obesity Landmark clinical trial demonstrating weight loss outcomes National Institutes of Health GLP-1 receptor agonists for obesity treatment Mechanism and long-term effectiveness
Overall, adverse events were predominantly mild to moderate and did not lead to treatment discontinuation in most cases