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In this work, small molecule fragments obtained by X-ray crystallography are ligated and partially optimized as non-covalent, and orally bioavailable inhibitors of TGR

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After the reactions, the samples were centrifuged by using a high-speed centrifuge machine (Avanti J25, Beckman)

Luna C, Mendoza N, Casao A et al (2017) c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways link capacitation with apoptosis and seminal plasma proteins protect sperm by interfering with both routes