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10.1152/physrev.00015.2016 Physiol

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In CD4 T cells, the lack of NOX2 induces Th17 cell production and reduces regulatory T cells in a ROS-dependent manner through the modulation of the transcription factors Foxp3 and RORt [153]

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This finding is in line with the improved tolerance achieved by engineering GSH biosynthesis even in the obligate anaerobe Clostridium acetobutylicum against aeration and butanol challenge [67]

doi: 10.1016/j.ijpharm.2018.11.065