Bray GA, Heisel WE, Afshin A, Jensen MD, Dietz WH, Long M, et al
Beyond weight loss, these medications improve multiple metabolic parameters including hemoglobin A1c, blood pressure, and lipid profiles
Despite its benefits, semaglutide is not without side effects
Benadryl: Side effects and cautions
Although all unimolecular triple agonists in phase 2 trials for obesity are GLP1/GIP/GCG triple agonists, there is an ongoing phase 2 clinical trial of bioglutide, an oral insulin-like-growth factor-1 (IGF-1)/GLP-1/GIP/GCG quadruple agonist (NCT06564753) for individuals with obesity, which is also being trialled in combination with tirzepatide (NCT06643728)
The release of proglucagon causes the liver to make glucose (gluconeogenesis converting protein to glucose) as well as to convert fatty acids into ketone bodies