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10.3390/antiox10111745 Antioxidants
Studies demonstrated significant reductions in visceral adipose tissue (VAT) within 6 to 12 weeks of consistent daily administration, with effects maintained for the duration of treatment
Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction
Silicic acid or silicon dioxide in dietary supplements has been discouraged
However, the peptide also affects subcutaneous fat, particularly in areas with adequate beta-3 receptor expression