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Furthermore, it has been shown that endothelin-1 and VEGF, which are responsible for enhanced vascularity in melasma lesions, can be diminished by tranexamic acid administration

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In the gastrointestinal tract, COX-1-derived prostaglandins function to increase production of the thick mucus/bicarbonate layer that coats gastric surfaces and buffers them against stomach acid (Vonkeman 2010)

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