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The debate was reignited in 2025 when several large-scale analyses re-examined the association between GLP-1 therapy and pancreatic inflammation

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It has been shown that dysregulation of the expression of GLP-1 and GIP receptors and impairment of insulin receptor substrate 1 (IRS-1) are implicated in the development and progression of neurodegenerative diseases such as Alzheimers disease (AD) (Talbot et al

In the most recent American Association of Clinical Endocrinology clinical practice guidelines for the diagnosis and management of NAFLD it was recommended to administer pioglitazone (PIO) or glucagon-like peptide 1 receptor (GLP-1R) agonists with proven benefit for patients with T2D and biopsy-proven NASH, while these medications should be considered when there is high probability of having NASH (based on higher plasma aminotransferase levels and non-invasive tests) [40]