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Aviles-Olmos I, Dickson J, Kefalopoupou Z, Djamshidian A, Kahan J, Ell P, et al

Imaging and single-cell transcriptomic analyses demonstrate that SGLT2 inhibitors and GLP-1 receptor agonists improve kidney tissue oxygenation and perfusion, respectively [124], and act on distinct kidney cell types [125,126], reinforcing a biological basis for additive or synergistic effects

By acting on these three receptors simultaneously, retatrutide offers a more potent approach to weight loss compared to current medications, as it works on multiple pathways to target obesity from various angles

Structure/activity characterization of glucagon-like peptide-1

10.1194/jlr.M800221-JLR200 42 van VliesN.TianL.OvermarsH.BootsmaA

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