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As a result, B 2 deficiency can trigger functional folate deficiency, especially in carriers of MTHFR mutations associated with reduced activity of the MTHFR enzyme

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In practice, the translational utility of follicular-fluid profiling will hinge less on single-marker significance than on whether cross-omic signatures remain stable under standardized pre-analytics and batch-aware normalization, enabling assay compression into reproducible panels compatible with routine ART workflows

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