allodynia and tirzepatide Pharmacovigilance analysis of neurological adverse events associated with GLP-1 receptor agonists based on the FDA Adverse Event Reporting System Tirzepatide for Medical Weight Loss

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In decompensated cirrhosis, patients are symptomatic, due to significant fibrotic changes, and present with one or more of the following: ascites, jaundice, hepatic encephalopathy, or variceal hemorrhage.(2) Of note cirrhosis is one of five conditions encompassed by the broad category metabolic dysfunction-associated steatotic liver disease (MASLD).(3) Background: How GLP-1 RAs Work and Potential Cirrhosis Benefit GLP-1 RAs stimulate prandial insulin secretion, limiting glucagon production, slowing gastric motility and increasing satiety

Of the participants, 80.8% of the 2.5 mg VK2735 group, 97% of the 5 mg dose group, 93.8% of the 10 mg VK2735 group and 100% of the 15 mg dose group lost 5% or more body weight at 13 weeks