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The National Heart, Lung and Blood Institute Heart Failure Clinical Research Network designed the Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT) study (NCT01800968) to test the hypothesis that liraglutide would improve myocardium bioenergetics leading to post-hospitalization clinical stability in subjects with advanced HF and reduced left ventricular ejection fraction, with and without diabetes [47]

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These concepts have influenced the manner in which new technologies are evaluated in clinical trials, where conditions most conducive to a successful therapy (i.e., green knees) are selected for initial trials in humans

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