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Elecoglipron is being developed as a tabletbased GLP1 therapy for adults with type 2 diabetes and for people living with obesity or overweight with weightrelated comorbidities. In type 2 diabetes, the Phase IIb SOLSTICE trial (NCT06579105) evaluated several oral doses of elecoglipron versus placebo and an active oral GLP1 comparator, with change in HbA1c at 26 weeks as the primary endpoint

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Parag Mallick, chief scientist at Nautilus Biotechnology, says he thinks the field is understanding now more than ever that tau is not a single protein that goes up and down. For example, in a single-molecule study that Mallick and his team posted to bioRxiv, researchers identified at least 130 different tau proteoforms in brain organoids and donor tissue