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In the largest trial so far, people on retatrutide lost an average of 28.7% of their body weight over about 16 months

Applying these data to patients with diabetes who are at lower cardiovascular risk can be challenging and should incorporate patient-centered shared decision-making

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Regular monitoring should include HbA1c, renal function, weight, and retinal assessment in patients with pre-existing diabetic retinopathy

3.1.2 The distinct mechanisms of lipid peroxidation in I/R AKI Excessive lipid peroxidation is a defining hallmark of ferroptosis, with its dysregulation directly contributing to renal I/R-induced AKI

Aging (Albany NY) 16 (2), 19251937