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Adverse Reactions/Side Effects The following clinically significant adverse reactions are described elsewhere in the labeling: Disturbance in Sexual Arousal [see Warnings and Precautions (5.1)] Depression and Suicidal Ideation [see Warnings and Precautions (5.2)] Hypersensitivity Reactions [see Warnings and Precautions (5.3)] Skin Hyperpigmentation, Darkening of Pre-Existing Nevi, and Development of New Melanocytic Nevi [see Warnings and Precautions (5.4)] Acute Adrenal Insufficiency in Patients with Acquired HO [ see Warnings and Precautions (5.5)] Sodium Imbalance in Patients with Acquired HO and Central Diabetes Insipidus [ see Warnings and Precautions (5.6)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

Women in perimenopause and menopause Hormonal transitions create unique sleep challenges

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Braz J Biol 82:e267633 Alghamdi HY, Alrashed AM, Jawhari AM, Abdel-Moneim AS (2022) Neuropsychiatric symptoms in post-Covid-19 long haulers

Reduced potency

1]) and in achieving the three HbA 1c targets (ESM Table 1)