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These radicals, in conjunction with superoxide anions and doxorubicin itself, can cause DNA damage [224], and disrupt protein and lipid metabolism, ultimately resulting in cardiac tissue harm

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For instance, oxidized AAT inhibits inflammation in response to cigarette smoke in vivo 155 and induces a broad anti-inflammatory profile in gene expression of primary human lung microvascular endothelial cells

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Moreover, the brain ventricles contain highly vascularized structures, the choroid plexus, composed of fenestrated blood vessels and epithelia sealed by tight junctions

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