Tracking your symptoms when starting a GLP-1 drug can help you understand how your body responds
A patient with unexplained fatigue should be worked up, not injected masking a B12 deficiency of unclear cause, or an unexamined thyroid problem, with a monthly shot is a real clinical risk
Active compound in FDA-approved Vyleesi
After absorption, B12 is bound to transport proteins, 7580% to haptocorrin, which transports B12 in the blood, and 2025% to transcobalamin, which delivers B12 to the tissues, also referred to as active B12 or holo-transcobalamin
When using GLP-1 medications, identifying these factors can help you decide what to change
In fact, PCP was noted to induce vacuolar formations in cingulate and retrosplenial cortex associated with the induced psychosis if used for brief periods (Olney et al., 1989), while more prolonged use resulted in neuronal degeneration in cerebro-cortical and limbic brain regions (Seamans, 2008)