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In the team different types of inhibitors (reversible, irreversible) were early designed in the 1,4- naphthoquinone (NQ) series to evaluate the impact of each inhibition mode on the growth of the parasites: uncompetitive or catalytic inhibitors and fluorine-based suicide-substrates, dual prodrugs based on disulfide reductases inhibitors

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Human trials improved memory scores in adults with mild cognitive impairment reduced inflammatory markers associated with neurodegeneration Mechanism suppresses neuroinflammation signals from the gut alters tryptophan metabolism (affecting serotonin pathways) Strength of evidence: Very promising for memory 4

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