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When fat builds up in the liver, it can lead to fibrosis (buildup of scar tissue) and cirrhosis (hardening of the liver), which can lead to liver cancer

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Numerous studies have demonstrated that E2 exerts an inhibitory effect on HIF-1 expression (17, 28, 68), aligning with the mechanisms through which OSAHS induces cellular autophagy, suggesting that E2 may modulate autophagy via the HIF-1 pathway

Iliceto M, Stensen MH, Andersen JM, Haugen TB, Witczak O

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Clinical studies have shown patients can lose approximately 15% or more of their body weight over a one-year period, with the most significant results often occurring within the first six months