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The total thiol and GSH levels in livers are markedly reduced in untreated STZ-induced diabetic rats

In: StatPearls [Internet] 2020

Users should never exceed recommended dosages, as doing so can lead to an increased likelihood of side effects and complications

Morris G, Anderson G, Dean O, Berk M, Galecki P, Martin-Subero M, et al

Hypertoxic self-assembled peptide with dual functions of glutathione depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis

More recently, safety and limited but significant efficacy of Ebselen has been shown in humans (Kil et al., 2017), supporting interventions on enzymatic activities in glutathione metabolic routes as a promising therapeutic avenue