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Key research areas under investigation include: Receptor-ligand selectivity studies Transcriptional regulation of melanogenic pathways Eumelanin synthesis mechanisms cAMP-dependent gene expression Neurobiological signaling in CNS models Inflammation-associated molecular endpoints Metabolic pathway interrogation These findings remain experimental and preclinical in nature, with all observations restricted to controlled laboratory and animal model systems

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Cell Metab 30 , 987996.e6 (2019)

For this review article, a comprehensive literature search was conducted using PubMed Central, Google Scholar, and Scopus databases