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Meta-analysis of these eight CVOTs with 60 080 patients included showed that GLP-1 receptor agonists reduce MACE and have a positive impact on chronic kidney disease in patients with T2D ( Dose-dependent effect for oral semaglutide was assessed and proven in Japanese PIONEER 9 trial, where greater reduction of HbA1c and weight loss was achieved with higher dose of oral semaglutide compared to placebo and 0.9 mg liraglutide (46)

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