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Keywords: GLP-1RA, Model-based meta-analysis, Obesity, Weight reduction Graphical abstract Highlights Offers a detailed comparison of the efficacy, potential influencing factors and safety profiles among various GLP-1RAs

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L-Carnitine, Lycopene, and Zinc help provide the essential nutrients to the body

Metformin, a biguanide derivative, has been a mainstay in treating type 2 diabetes for over six decades, primarily through inhibiting hepatic gluconeogenesis and increasing muscle insulin sensitivity

SASA analysis indicated that the solvent-accessible surface area of the GPX3Diosgenin complex ranged from 95 to 110 nm, with no significant change in structural exposure after binding ( Figure 9F )

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