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Free radicals are unstable molecules that contain unpaired electrons, which can cause damage to cells, proteins, and DNA

An instant vascular inflammatory response, though initially protective against such threats, can become detrimental if excessive or chronic

In vivo , intraperitoneal administration of the NRF2 activator RTA-408 significantly upregulated NRF2 expression in neurons of SOD1 G93A transgenic mice, which consequently elevated the expression of GSH, SLC7A11, and GPX4, reduced MDA and ROS levels, suppressed neuronal ferroptosis, lipid peroxidation, and mitochondrial injury, and ameliorated weight loss and motor dysfunction in mice (Yang et al., 2023)

These studies reveal that mTOR signaling activation is required for -cell proliferation

[104] Transurethral incision of the prostate (TUIP): rarely performed