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Interestingly, reintroducing cytoplasmic GPX4, rather than its mitochondrial or nuclear counterparts, can rescue the lethal phenotype in Gpx4 -null mice [119]

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17 The maintenance of iron homeostasis plays a key role in vital processes such as erythropoiesis, energy metabolism of muscle, cell cycle regulation, hormone production, immune system function, heme synthesis, DNA replication and repair, brain development and aging, and the formation of cytochromes