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2021) and increases with leaf age in Arabidopsis (Koffler et al

This review explores gut dysbiosis across a broad spectrum of conditions, including neurodegenerative diseases (e.g., AD, PD, ALS), psychiatric disorders (e.g., MDD, BD, PTSD, anxiety), autoimmune syndromes (e.g., MS), and neuroinflammatory or toxic exposures (e.g., radiation, xenobiotics)

Heavy NNMT activity drains the methyl group supply, affecting all those downstream methylation reactions

Chini CCS, et al

A range of endocrine organs can be affected, including the pituitary, thyroid, pancreas, and adrenal glands