The drug is metabolized primarily through proteolytic cleavage and does not undergo hepatobiliary excretion as an intact molecule
Oral GLP-1 therapies can expand the market, but they may not completely overtake injectables
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Ultimately, were still in the early stages of understanding what GLP-1 agonists are capable of, but with countless research teams all taking a closer look at the meds, it wont be long before we have answers and potentially a new way to treat everything from addiction to Alzheimers
Schmidtko, A
To date, cardiovascular outcome studies show that GLP-1 receptor (GLP-1R) agonists reduce atherosclerotic events including myocardial infarction and stroke, and also prevent progression of chronic kidney disease in type-2 diabetic patients [3,4,5]