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Severe hepatic or renal impairment high-dose protocols may add metabolic burden

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Leptin-targeting anti-leptin treatments are still in the research and exploratory stage, however, and more empirical and theoretical evidence based on the leptin signaling pathway is needed to develop novel therapeutic approaches for clinical metabolic or immunological diseases

556 Consequently, researchers believe that HIF-1 may serve as a mechanism for cells to rapidly respond to acute hypoxia, whereas HIF-2 may be more relevant in chronic hypoxic responses

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