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Possible causes include pregnancy, excessive caloric restriction, body fat dropping below the threshold for menstruation (typically 18% to 20%), or changes in ovulation timing

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Candidate transporters and receptors involved in colistin uptake across the brush-border membrane of the proximal tubular cells are the Glycosylphosphatidylinositol (GPI)-anchored protein megalin 13 , the human peptide transporter 2 (PEPT2, SLC15A2 ) and the carnitine/organic cation transporter 2 (OCTN2, SLC22A5 ) 14,15

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